Terbinafine/betamethasone acetate

Terbinafine/betamethasone acetate, sold under the brand name Duotic is a veterinary medication used for the treatment of otitis externa (ear infections) in dogs. It is a fixed dose combination of terbinafine, an antifungal; and betamethasone acetate, a glucocorticosteroid anti-inflammatory.

The combination is the first FDA-approved animal drug intended to treat yeast-only otitis externa in dogs. It is also the first otic drug intended to treat otitis externa that does not contain an antibiotic.

Terbinafine/betamethasone acetate was approved for medical use in the United States in March 2024.

Veterinary uses
Terbinafine/betamethasone acetate is indicated for the treatment of otitis externa in dogs, associated with susceptible strains of yeast (Malassezia pachydermatis).