Thallium(III) trifluoroacetate

Thallium(III) trifluoroacetate (TTFA) is the chemical compound with the formula Tl(O2CCF3)3. It is used as a reagent in the synthesis of some organic compounds for research purposes. Thallium is to toxic to be directly useful in medicinal chemistry. The compound has not been characterized by X-ray crystallography, so the representation shown above is probably simplified.

TTFA reacts directly with arenes to afford organothallium(III) derivatives. It is also used to difunctionalize alkenes. For example, alcohol solutions of this reagent convert simple alkenes to glycol derivatives.