The Big Question

The Big Question may refer to:
 * The Big Question (comics), a.k.a. Enigma Fisk, a fictional character in Amalgam Comics
 * The Big Question (TV series), a five-part television series exploring the evolution of the universe and life, broadcast on Channel 5 in 2004 and 2005
 * The Big Question (novel), a 2007 novel by Chuck Barris