Thiocyanate hydrolase

A thiocyanate hydrolase is an enzyme belonging to the family of hydrolases. The systematic name of this enzyme class is thiocyanate aminohydrolase. This enzyme catalyzes the chemical reaction:
 * SCN- + 2 H2O + H+  <-> SCO + NH3

The mechanism is proposed to involve a metal thiocyanate complex.

Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes, , , and.

A second thiocyanate hydrolase with copper at its active site catalyzes its conversion to cyanate:
 * SCN- + H2O   ->  OCN-  +  H2S