Thomas Clayton (disambiguation)

Thomas Clayton (1777–1854) was an American lawyer and politician.

Thomas Clayton may also refer to:


 * Thomas Clayton the Elder (1575-1647), physician and Regious Profess of Anatomy, Oxford
 * Thomas Clayton (physician) (c. 1612–1693), MP for Oxford University
 * Thomas Clayton (composer) (1673–1725), English musician and opera composer
 * Thomas Clayton (American football) (born 1984), American football running back
 * Tom Clayton (jockey) (1882–1909), Australian jockey
 * Tom Clayton (footballer) (born 2000), English footballer
 * Thomas J. Clayton (1826–1900), President Judge of the Thirty-Second Judicial District of Pennsylvania