Threonine synthase

The enzyme threonine synthase (EC 4.2.3.1) catalyzes the chemical reaction
 * O-phospho- L -homoserine + H2O $$\rightleftharpoons$$ L -threonine + phosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is O-phospho- L -homoserine phosphate-lyase (adding water L -threonine-forming). Other names in common use include threonine synthetase, and O-phospho- L -homoserine phospho-lyase (adding water). This enzyme participates in glycine, serine and threonine metabolism, and vitamin B6 metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , and.