Trans-resveratrol di-O-methyltransferase

Trans-resveratrol di-O-methyltransferase (, ROMT, resveratrol O-methyltransferase, pterostilbene synthase) is an enzyme with systematic name S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase. This enzyme catalyses the following chemical reaction


 * 2 S-adenosyl-L-methionine + trans-resveratrol $$\rightleftharpoons$$ 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction)
 * (1a) S-adenosyl-L-methionine + trans-resveratrol $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene
 * (1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + pterostilbene

The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.