Triazolobenzodiazepine

Triazolobenzodiazepines (TBZD) are a class of benzodiazepine (BZD) derivative pharmaceutical drugs. Chemically, they differ from other benzodiazepines by having an additional triazole ring fused to the diazepine ring. The triazole and diazepine rings share a nitrogen atom.

Examples include:
 * Adinazolam
 * Alprazolam
 * Bromazolam
 * Clonazolam
 * Estazolam
 * Flualprazolam
 * Flubromazolam
 * Flunitrazolam
 * Nitrazolam
 * Pyrazolam
 * Triazolam
 * Zapizolam

Synthesis
Synthesis of 1-methyltriazolobenzodiazepines (alprazolam type) is possible by heating 1,4-benzodiazepin-2-thiones with hydrazine and acetic acid in n-butanol under reflux.