Tryptophan N-monooxygenase

Tryptophan N-monooxygenase (, tryptophan N-hydroxylase, CYP79B1, CYP79B2, CYP79B3) is an enzyme with systematic name L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction


 * L-tryptophan + 2 O2 + 2 NADPH + 2 H+ $$\rightleftharpoons$$ (E)-indol-3-ylacetaldoxime + 2 NADP+ + CO2 + 3 H2O (overall reaction)
 * (1a) L-tryptophan + O2 + NADPH + H+ $$\rightleftharpoons$$ N-hydroxy-L-tryptophan + NADP+ + H2O
 * (1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ $$\rightleftharpoons$$ N,N-dihydroxy-L-tryptophan + NADP+ + H2O
 * (1c) N,N-dihydroxy-L-tryptophan $$\rightleftharpoons$$ (E)-indol-3-ylacetaldoxime + CO2 + H2O

Tryptophan N-monooxygenase is a heme-thiolate protein (P-450).