Twiggs

Twiggs may refer to:

In ships:
 * USS Twiggs (DD-127), a US Navy destroyer during World War I
 * USS Twiggs (DD-591), a US Navy destroyer during World War II


 * Geography
 * Twiggs County, Georgia
 * Twiggs, West Virginia

People with the surname Twiggs:
 * David E. Twiggs (1790–1862), US soldier during the War of 1812 and Mexican War, and a general in the Confederate States Army during the American Civil War
 * John Twiggs (1750–1816), leader in the Georgia Militia during the American Revolutionary War
 * Levi Twiggs (1793–1847), officer in the US Marine Corps during the War of 1812, the Seminole Wars and the Mexican–American War
 * Sarah Lowe Twiggs (1839-1920), American poet