Twomile Creek

Twomile Creek may refer to:


 * Twomile Creek (Chattahoochee River tributary), a stream in Georgia
 * Twomile Creek (Marmaton River), a stream in Missouri
 * Twomile Creek (North Fork Salt River), a stream in Missouri
 * Twomile Creek (Warm Fork Spring River), a stream in Missouri
 * Twomile Creek (Uwharrie River tributary), a stream in Randolph County, North Carolina
 * Twomile Creek (East Branch Oil Creek tributary), a stream in Crawford County, Pennsylvania
 * Twomile Creek (Kanawha River), a stream in West Virginia
 * Twomile Creek (Nepco Lake tributary), a stream in Wisconsin
 * Two Mile Creek (Yellow River tributary), a stream in Wisconsin