Tyrosine N-monooxygenase

Tyrosine N-monooxygenase (, tyrosine N-hydroxylase, CYP79A1) is an enzyme with systematic name L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction


 * L-tyrosine + 2 O2 + 2 NADPH + 2 H+ $$\rightleftharpoons$$ (Z)-[4-hydroxyphenylacetaldehyde oxime] + 2 NADP+ + CO2 + 3 H2O (overall reaction)
 * (1a) L-tyrosine + O2 + NADPH + H+ $$\rightleftharpoons$$ N-hydroxy-L-tyrosine + NADP+ + H2O
 * (1b) N-hydroxy-L-tyrosine + O2 + NADPH + H+ $$\rightleftharpoons$$ N,N-dihydroxy-L-tyrosine + NADP+ + H2O
 * (1c) N,N-dihydroxy-L-tyrosine $$\rightleftharpoons$$ (Z)-[4-hydroxyphenylacetaldehyde oxime] + CO2 + H2O

Tyrosine N-monooxygenase is heme-thiolate protein (P-450).