UCSC

UCSC may refer to:


 * University of California, Santa Cruz, a public university in Santa Cruz, California
 * Università Cattolica del Sacro Cuore, a private Catholic university based in Milan, Italy
 * University of Colombo School of Computing, a college affiliated with the University of Colombo in Sri Lanka
 * University City Science Center, an urban research park in Philadelphia, Pennsylvania, United States
 * Catholic University of the Holy Conception, a private catholic university in Chile