UPB

UPB may refer to:


 * Union of Poles in Belarus
 * Universal Powerline Bus, a proprietary home automation protocol (2003)
 * Universidad Pontificia Bolivariana
 * University of Paderborn
 * University of Pittsburgh at Bradford
 * University of the Philippines Baguio
 * University POLITEHNICA of Bucharest

Upb may refer to:
 * Unpentbium, an unsynthesized chemical element with atomic number 152 and symbol Upb