USSC

USSC may refer to:

Government

 * United States Supreme Court, the highest federal court of the United States
 * United States Sentencing Commission, an agency responsible for stating the sentencing guidelines for the United States federal courts

Military

 * United States Space Command, a unified combatant command of the U.S. Armed Forces
 * United States Sanitary Commission, a relief agency that supported injured soldiers of the U.S. Army during the American Civil War

Other uses

 * United States Steel Corporation
 * United States Studies Centre, a non-profit organization headquartered at University of Sydney
 * United States Surgical Corporation, a former manufacturer of medical devices