U of SA

U of SA, U. of SA, U of S.A., or U. of S.A. may refer to:
 * University of South Africa, in South Africa
 * University of Texas at San Antonio, in Texas
 * University of San Antonio, in Texas
 * University of St Andrews, in the United Kingdom
 * University of Saint Anthony, in the Philippines
 * Union of South Africa, the official name of South Africa from 1910 to 1961