Up Against It (disambiguation)

Up Against It was an unproduced script by Joe Orton, written in 1967.

Up Against It may also refer to:
 * Up Against It!, a 1997 album by Todd Rundgren
 * Up Against It (film), a 1912 romantic comedy directed by Otis Turner
 * Up Against It (album), a 1986 album by The Times
 * "Up Against It", a song by Pet Shop Boys from the album Bilingual