Upper Main Street Historic District

Upper Main Street Historic District may refer to:


 * Upper Main Street Historic District (Ansonia, Connecticut)
 * Upper Main Street Historic District (Lafayette, Indiana)
 * Upper Main Street Historic District (Dubuque, Iowa)
 * Upper Main Street Historic District (Hatfield, Massachusetts)
 * Upper Main Street Historic District (Menasha, Wisconsin), listed on the National Register of Historic Places in Winnebago County, Wisconsin