User:Алексей Черныш/sandbox

Allostatine is a synthetic peptide which shows selective activity against natural killer cells [1]. Allostatine is composed of 13 amino acids (HGVSGWGQHGTHG) and includes the domain (SGWGQ-GT) in common with the region of CDR3 of immunoglobulins in mammals which is not found in natural alloferon [2]. It has been shown that this change in the structure of the peptide enhances the recognition of weak antigens by cytotoxic cells.

[ 1 ] Chernysh S., Kozhukharova I. Anti-tumor activity of a peptide combining patterns of insect alloferons and mammalian immunoglobulins in naïve and tumor antigen vaccinated mice // International Immunopharmacology. — 2013 — Vol. 17, №4 — P.1090—1093. — DOI:10.1016/j.intimp.2013.10.014

[ 2 ] Chernysh S., Kim S. I., Bekker G., Pleskach V. A., Filatova N. A. Antiviral and antitumor peptides from insects // Proceedings of the National Academy of Sciences. — 2002 — Vol. 99, no. 20 — P. 12628—12632 — DOI:10.1073/pnas.192301899