User:さらでいん/METTL9

METTL9 (Methyltransferase like 9) is a protein encoded by the genome of the same name located on chromosome 16 in human. The protein polypeptide chain has a length of 318 amino acids and a molecular weight of 36,536

Histidine methyltransferase catalyzes methylation of histidine, an amino acid in mammalian proteomes.

Function
Protein methylation is one of the post-translational modifications. METTL9 catalyzes the methylation reaction in which a methyl group is transferred to a nitrogen atom with an unshared electron pair in the histidine side chain within a protein polypeptide.

Histidine methyltransferase catalyzes methylation of histidine, an amino acid in mammalian proteomes.

METTL9 tends to target the ANGST HXH motif, which is an alternating sequence of histidine and other amino acids. In addition, such sequence motifs are often the metal binding sites of proteins, and the metal binding motifs (HxH motifs) of NDUFB3, SLC39A7, and S100A9 (mouse) are actually methylated by METTL9.

Process
In in vitro studies, peptides methylated His-107, which is responsible for the metal binding of mouse S100A9, have diminished zinc binding activity. NDUFB3 is a co-subunit of mitochondrial complex Ⅰ, where the HXH motif histidine coordinates zinc ions, but METTL9KO cells (cells lacking METTL9) consume less oxygen. It has been suggested that methylation of zinc transporter SLC39A7 may be involved in zinc storage and release.

Clinical significance
High expression of METTL9 may be involved in cancer progression, as METTL9 is significantly increased in some cancer cells. The very high expression of METTL9 and S100A9 in neutrophils may be involved in the innate immune response to bacterial infections and inflammation.

関連項目

 * 翻訳後修飾
 * リン酸化
 * アセチル化
 * ユビキチン化
 * メチル化
 * ヒスチジン
 * イミダゾール環
 * メチルトランスフェラーゼ
 * S-アデノシルメチオニン
 * SETD3
 * S100A9