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There are two groups of autoimmune pathophysiology. The first group consists of classic paraneoplastic disorders, which occur due to cancer elsewhere in the body. This type of encephalitis is related to intracellular antigens. The second group is characterized by autoantibodies to cell-surface antigens. The antigens and mechanisms of several forms of autoimmune encephalitis such as lupus cerebritis and acute disseminated encephalomyelitis are not well established.