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=IFFO1 Gene=

Introduction
IFFO1 stands for Intermediate Filament Family Orphan 1. According to GeneCards, IFFO1 is also called Intermediate Filament Family Orphan, HOM-TES-103, Intermediate Filament-Like MGC: 2625, and Tumor Antigen HOM-TES-103. In addition, this gene can be found on Chromosome 12p13.3 and it contains 17,709 nucleotide bases.

Features
Some organisms that were found to be homologs were mouse, chicken, lizard, African clawed frog, zebrafish, Alicante grape, and rice.2 Within the same NCBI search, a few characteristics regarding the gene were found. IFFO1 generates a product called ‘intermediate filament family orphan 1 isoform X1’. Upon further research using PubMed, OMIM, Google, and NCBI, nothing was found about this product. Currently, the structure of the protein has not been identified. A unique filament region was found in the sequence between 230bp and 529bp.1 With regards to the proteins for IFFO1 gene, GeneCards indicates that there are 559 amino acids with the molecular weight of 61,979 Da. Due to alternative splicing, there are 7 isoform of IFFO1. The modification sites were identified from PhosphoSitePlus along with the basal isoelectric point of 4.83.

Publications and Disease Associations
Currently, there are only two publications were found in PubMed after using each of the aliases as keywords. The first publication, “Genome-Scale Screen for DNA Methylation-Based Detection Markers for Ovarian Cancer”, states that a biomarker named IFFO1 promoter methylation has some correlation with ovarian cancer. However, the article fails to explain more about the marker and whether it has any relation to the IFFO1 gene. IFFO1 was not mentioned in any of the references either. The second article, “A Novel Tumour Associated Leucine Zipper Protein Targeting to Sites of Gene Transcription and Splicing”, was found while using the alias “HOM-TES-103”. Unfortunately, the article was focusing on LUZP4 gene or also known as HOM-TES-85 that has a particular leucine zipper region associated with cancer. NCBI also provided a number for IFFO1 in the OMIM database. Upon opening the OMIM page on IFFO1, there was no information on any diseases that could potentially be associated with this gene.