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Silver
Silver mechanism of action includes disruption of multiple bacterial cellular processes (disulfide bond formation, metabolism, and iron homeostasis), which may lead to increased production of reactive oxygen species, and increased cell membrane permeability. In both mouse model and in vitro, evidence suggests that silver may increase the activity and potentially restore antibiotic susceptibility to antibiotic resistant bacterial. In one study, silver sensitized gram-negative bacteria in mouse and in vitro to vancomycin, "thereby expanding the antibacterial spectrum of this drug." Finally, "both in vitro and in a mouse biofilm infection model that silver can enhance antibacterial action against bacteria that produce biofilms."