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Psoriasis susceptibility 1 candidate 2 (PSORS1C2) is a protein in humans encoded by the PSORS1C2 gene located on chromosome 6p21.33. PSORS1C2 has the alias chromosome 6 open reading frame 17 and is primarily found in the extracellular region. PSORS1C2 is found in mammals and its high expression in the skin is associated with influencing the onset of psoriasis.

Gene
PSORS1C2 is a protein coding gene and has 2 exons and spans 434 base pairs. It has the alias chromosome 6 open reading frame 17 (C6orf17) and it is located on chromosome 6 (p21.33) with associations to the skin disorder psoriasis.

Expression

It is highly expressed within the skin and minimally expressed in the testis. In addition, techniques like the Northern blot analysis have revealed that the expression of the PSORS1C2 gene in mice and pigs are very similar to that of a human.

Protein
PSORS1C2 has a theoretical molecular weight of 15.1 kDa and theoretical pI of 4.5. There are no alternatively spliced RNA variants. In addition, it is primarily located in the extracellular region. It is proline and tryptophan rich with a KR-ED of -24 making it more acidic than average.

Post-translational Modifications

SignalIP predicted that there is a signal peptide signal at amino acids 22 and 23 with a cleavage site from amino acids 1 to 22 in the sequence .PSORS1C2 has a single acetylation site.

Interactions

It is related to a few genes such as CCHR1, CDSN, and PSORS1C1 that aid keratinocyte proliferation regulation, epidermal barrier integrity, and psoriasis susceptibility.

Homology and Evolution
Paralogs

PSORS1C2 has a single paralog called PSORS1C1 It is 152 amino acids long and has 2 exons. Similarly to PSORS1C2, it is thought to confer susceptibility to psoriasis and systemic sclerosis.

Orthologs

Genomic analysis of chromosome 6 showed PSORS1C2 is only present in mammals.

Clinical Significance
PSORS1C2 in collaboration with antigens on HLA-6 influence the onset of psoriasis