User:A3C7/Human polyomavirus 2

The article on human polyomavirus 2 is a little underdeveloped, but overall it has a good overview of the virus and provides good information on its epidemiology, infection, pathogenesis, and other syndromes associated with the virus. This article has a neutral tone and provides good, factual information about human polyomavirus and its impact on humans. One area in which it could be developed is talking about the structure and lifecycle of the virus. It does not discuss which proteins are involved, how it gets into cells, or how it replicates and survives. One thing that this article does have a lot of is sources. There is a lot more information available that could be added to this article.

Sources that could be helpful:

Journal Entry:

Week of 9/21 - 9/26

The article on Dengue virus is more in-depth than my article. One big thing that my article is lacking is the protein structures on the virus and the virus' lifecycle. This is important information that could be added to my article on human polyomavirus 2. The Dengue article lists each protein and why it is important for the virus, while the article I chose does not even have the proteins listed. Another different is the lifecycle. The article about Dengue virus has two full paragraphs describing the virus' lifecycle, while the human polyomavirus 2 does not even mention the lifecycle of the virus or the steps that the virus undergoes to get into the cell and replicate. My article does have a solid section about the epidemiology, and infection and pathogenesis. Another interesting section that my article has is about drugs that are associated with reactivation of the virus. Another good section that the Dengue virus article has is how the virus interacts with the immune system. My article on human polyomavirus 2 does not talk much about the immune system and how it reacts to and tries to fight off the viral infection.

The sections that I want to add to this article is the virus' lifecycle and the proteins on the virus and how each of them functions and why they are important. These are important aspects of a virus and they are important additions to this article. Knowing the proteins on the virus and how it gets into the cell and replicates is important for understanding the virus and developing drugs to prevent it from getting into cells.

Journal Entry:

Week of 9/28 - 10/3

LifeCycle
In the first step of the replication cycle, the protein VP1 on the virus attaches to the host cell's sialic acid receptors. These can be either alpha 2,3 or alpha 2,6 linked sialic receptors. There is evidence that an addition serotonin receptor is also necessary for entry. The next step in the lifecycle is to be transported into the cell using clatherin-dependent endocytosis. Once the virus has entered the host cell, it forms an endoscope and travels to the ER where uncoating begins. The viral DNA then travels into the nucleus where transcription begins. The main regulatory protein, T-Ag, is produced and binds to the viral genome so that replication can begin. This depends on the host cell's DNA polymerase. As replication begins, the late genes (VP1, VP2, and VP3) are expressed and assemble with the viral DNA to form a virion. This can then be released via host cell lysis. The lifecycle of human polyomavirus 2 is a slow process and DNA replication is not detected for several days.