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Structure
STRUCTURE

PTM cells are endothelial cells which are understood to have derived from mesonephric cells [1]. The structure and organization between PTM cells have been observed to be distinctly different between mammalian species. In humans, PTM cells are spindle shaped and form several thin elongated layers, approximately 5-7 cell layers, and surround sertoli cells.

These are detected in the lamina propria of the seminiferous tubule and immunohistochemical studies have shown functional distinctions between these layers. The inner layers have been shown to express desmin, a smooth muscle phenotype, whereas the outer layers express vimentin, a connective tissue phenotype [2]

In rodents, PTM cells are one layer thick. Both human and rodent PTM cells are are joined by junctional complexes. [2].

[1] Virtanen, I., Kallajoki, M., Näurväunen, O., Paranko, J., Thornell, L., Miettinen, M. and Lehto, V. (1986). Peritubular myoid cells of human and rat testis are smooth muscle cells that contain desmin-type intermediate filaments. The Anatomical Record, 215(1), pp.10-20.

[2] Maekawa M, Kamimura K, Nagano T. Peritubular myoid cells in the testis: their structure and function. Arch. Histol. Cytol. 1996; 59(1): 1-13