User:Aadharm/sandbox

The wikipedia page for the topic Histone Methylation is only a stub. It contains only the basic information on what the main purpose of Histone methylation is to the expression of genes as well as the where the methylation occurs on the histone, but little else. We, (Aadhar, Meghan and Colin), would like to expand this article by including more on how the methylation occurs, why it occurs, and the consequences of methylation on the current organism as well as future generations.

Topics:

Mechanism: Lysine and arginine residue structure and charge Degrees of methylation (mono-, di-, or trimethylation) and related function Positions that can be methylated Structure of histone and tails related to DNA structure Connection to transcriptional control Reversibility Methyltransferase: Structure S-adenosyl-methionine as the methyl group donor related diseases (cancer, Epigenetics: Discuss how certain genes are either activated or inactivated at birth how these are often passed down from one generation to another Histone methylation role in the activation or in activation of such genes Inactive X: Brief discussion of what inactive X is how histone methylation plays a large role Consequences of mutations: IDH mutation induces histone methylation increase in CNS-derived cells and can alter cell lineage gene expression. affects gene expression and development

Researchers look at methylation patterns to determine if cells are cancerous.