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Rhodopsin Kinase Related Eye Diseases.
Mutation in Rhodopsin Kinase can result in diseases such as Oguchi and Retinal degeneration. Oguchi disease is a form of Congenital stationary night blindness (CSNB). Congenital stationary night blindness is caused by the inability to send a signal from outer retina to the inner retina by signaling molecules. Oguchi disease is a genetic disorder so an individual can be inherited from his or her parents. Genes that are responsible for Oguchi disease are SAG and GRK1 genes. Rhodopsin Kinase is encoded from the GRK1 gene, so a mutation in GRK1 can result in Oguchi disease. The patients who have Oguchi disease will have difficulty seeing at night, also known as night blindness.

Retinal degeneration is a form of the retinal disease caused by the death of photoreceptor cells that present in the back of the eye, retina. Rhodopsin kinase directly participates in the rhodopsin to activate the "Phototransduction cascade". Studies have shown that lack of rhodopsin kinase will result in photoreceptor cell death. When photoreceptors cells die, they will be detached from the retina and result in retinal degeneration.