User:Aaron.aude/sandbox

== Five Core Pillars: ==


 * 1) This is an encyclopedia.  Not a soap box or means to advance a cause.  It should use elements of general information.
 * 2) This is to be factual, written from a neutral point of view.  Just the facts.
 * 3) Free content to use, edit modify, etc.  No licensing, royalties, and respect copyright laws when adding content.
 * 4) No firm rules.  Exceptions are okay, and be bold editing - others will come after you to fine tune your wording.

== Summary of characteristics of target article == An article between the level of "B" or "GA" is one that can stand on its own, and provides readers with enough detail that they are "not left wanting" but not yet at an encyclopedic level of quality. WikiProject's Article Quality Grading Scheme provides a suggestions as to how to improve a stub article to this level by adding the following:


 * 1) Reliable, prioritized sources
 * 2) Satisfy more than a casual reader's interest by adding detail and additional content
 * 3) Fine tune content and style (consistency in voice, structure)
 * 4) Involvement of an expert review of the content study.

Naturally Wikipedia has provided ample resources to aid in this process, both by reference articles at the various grade classes as well as example content, tone, style and peer review.

== PubMed Articles of Interest ==

Thyroid function and an underlying genetic basis for hormone concentration and expression has been an area of interest for many years. In the article "Genetics of Thyroid Function and Disease," Panicker describes "that up to 67% of circulating thyroid hormone and TSH concentrations are genetically determined." Panicker also explains that although "significant proportion of TSH, free T4 and free T3 variation is genetically derived, the genes responsible for this remain largely undetermined".

On another topic, the past unit of study, unit 5, highlighted an interesting facet of Rad51 foci and double strand break mediation. I became interested in how differences in Rad51 (its polymorphisms) could be implicated in cancers, as I understand BRCA2, Rad51 and leukemia (among other cancers) are linked. Of interest, Rad51 polymorphisms are implicated in colerectal cancer, specifically "Variant 135C allele", but specifically within the Polish population.