User:Aarzoomaknojia/sandboxweek4

In the Epigenetics of Depression article, wiki says medical references are needed to help develop the article. Recent findings like this one: show the possible effects of DNA methylation in depression. This can be used to help develop the article more by having adding a section on DNA methylation and the results found in. This also serves medical relevance as the findings were able to find that DNA methylation can play a role in predicting antidepressant treatment efficacy.

My worry is that these edits do not seem like very substantial additions, and these are already extensive articles. Outline a little bit more about how you can make more substantial additions to these articles. I think there's something there, but it needs to be developed a little more. Additionally, please make sure to provide a review article for your first proposal - I think this will also help you think about what else can be added. Wiki 6 Assignment

The Epigenetics of Depression article mentions the effects of the environment on the genome. The wiki article does not go into detail about this, so I think a section discussing depression and the environmental effects on the genome should be added. A recent study has found some significant findings on depression and environmental factors like stress, childhood maltreatment, and stressful life-events and how this is genome related. The article discusses gene-environment interactions (GxE) as markers for developing depression. The study evaluates "GxE interactions between stressful life events and the 5-HTTLPR variant" where the 5-HTTLPR variant expression was observed based on various stressful life events of individuals 21-26 years old.

The results indicated that patients with low-expressing 5-HTTLPR were associated with suicidal behaviors for the GxE of 5-HTTLPR and childhood trauma. This was also compared to intermediate- and high-expressing genotypes where the suicidal tendencies were not observed. Further study of this relationship was conducted to find that the short/short or short/long genotypes of 5-HTTLPR expression was linked to suicidal risk than the long/long genotype for children who experienced one or two types of maltreatment. This was different for children who experienced three to four types of maltreatment where forms of genotypes didn't matter and high levels of suicidal risk was observed.

Based on this study it was concluded that the three genes A2M, FoxO1, and TGF-B1 were determined to show significant GxE interactions with stressful life events that contributed to the development of depression. The identification of the genes and GxE interactions related to depression can be significant additions to this wiki article as the article seems to be missing information on the environmental effects on the genome and depression.

This paper also helps develop the wiki article because it's providing more relevant sources. This study also provides medical relevance to the wiki article by discussing a new part of epigenetics and depression. By introducing this study into the article, a new section is being added that is describing the epigenetics of depression from a different view point of the influences of environment. The identified genes can also be studied further for treatment of depression, something that further research would be needed.