User:Abhay Krishnaji Kulkarni/Sandbox

Bone Pain
Bone pain is the debilitating result of host of possible diseases. The motivation to aleviate bone pain stems from the fact that it is the leading factor in the decrease in quality of life for patients who suffer from it.

Causes
It has been known that bones are innervated with sensory neurons for many year. However, until recently, it was not determined what types of sensory nerves innervated which sections of bone. It is believed that activation of these sensory neurons relays signals to the brain resulting in the perception of bone pain.

Diseases leading to bone pain
List of diseases which could result in bone pain: osteoarthritis, Paget’s disease, sickle cell anemia, and bone cancer.

Pathophysiology
The human bone is a dense and tough structure that primarily serves to provide support the body and the connective tissue such as muscles and cartilage. Bone tissue can be divided into multiple sections based on morphology: bone marrow, mineralized bone, and periosteum. Each of these levels of bone have differing amounts of sensory neurons running through them, providing the brain with specific sensory inputs per location.

Current Treatment
A common method to alleviate bone pain which has been employed several years is the use of anesthetic within the actual bone. However, modern research and techniques are attempting to provide longer lasting and more effective methods of treating bone pain by developing and applying new physiological knowledge of nervous tissue within the bone.

Scientific Research
Mouse models are being heavily used to determine the neuron tissue densities in bone and mechanisms for maintenance of bone pain.