User:Ablake77/sandbox

LSMEM1
Leucine-rich single-pass membrane protein 1, or LSMEM1, is a human gene located on the q arm of chromosome 7 (7q31.1). Its mRNA is 1686 base pairs long, and its protein is 131 amino acid residues long. LSMEM1 goes by other names as well, including: c7orf53, chromosome 7 open reading frame 53, and FLJ39575.

Expression
LSMEM1's gene ontology is in the cytoplasm of cells, and as an integral membrane component. The LSMEM1 protein is more highly expressed in tissues such as cerebellum, kidney, testis, placenta, lung, colon, liver, heart, thyroid, and bladder.

Evolution
It also contains a domain of unknown function from mice called DUF4577, as well as an upstream in-frame stop codon. LSMEM1 has 5 different splice variants, only two of which are protein encoding. No paralogs exist of LSMEM1, so no gene duplication has occurred. LSMEM1 is a slowly evolving gene, which can be seen in comparison to the quickly evolving Fibrinopeptides and the slowly evolving Cytochrome C on the graph shown.

Homology
LSMEM1 is mainly conserved in mammals and some reptiles and birds.

Structure
The LSMEM1 protein is leucine-rich, and it has 19 leucine-rich repeats. In other proteins, leucine-rich repeats typically contribute to protein structural stability that aid protein-protein interactions.

Function
LSMEM1 protein also has been shown to be prevalent in the serum of patients with Parkinson's Disease and that it binds to diagnostic biomarkers of Parkinson's Disease as a protein antigen.