User:Abrault/TGFB1I1

To place after the existing starting sentence:

Often put together with and studied alongside TGFB1I1 is the mouse homologue HIC-5 ( Hydrogen Peroxide-Inducible Clone-5). As the name suggests, TGFB1I1 is an induced form of the larger family of TGBF1. Studies suggest TGBF1I1 plays a role in processes of cell growth, proliferation, migration, differentiation and senescence. TGBF1I1 is most localized at focal adhesion complexes of cells, although it may be found active in the cytosol, nucleus and cell membrane as well.

Function:

Transforming growth factor beta-1-induced transcript 1 plays a role in a number of cell functions. Originally, TGFB1I1 was isolated as a senescence-inducing gene from mouse osteoblastic cells through treatment with transforming growth factor beta-1 and hydrogen peroxide. During this, TGFB1I1 was also being independently discovered by numerous other groups and was characterized as a focal adhesion protein, an androgen and glucocorticoid receptor co-activator , a negative regulator of muscle differentiation , and major player in the recovery of arterial media.

Adding to References:

Hu Y, Cascone PJ, Cheng L, Sun D, Nambu JR, Schwartz LM. Lepidopteran DALP, and its mammalian ortholog HIC-5, function as negative regulators of muscle differentiation. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10218-23. doi: 10.1073/pnas.96.18.10218. PMID: 10468589; PMCID: PMC17869.

Ohanian J, Pieri M, Ohanian V. Non-receptor tyrosine kinases and the actin cytoskeleton in contractile vascular smooth muscle. J Physiol. 2015 Sep 1;593(17):3807-14. doi: 10.1113/jphysiol.2014.284174. Epub 2014 Dec 23. PMID: 25433074; PMCID: PMC4575570.

Kim-Kaneyama JR, Lei XF, Arita S, Miyauchi A, Miyazaki T, Miyazaki A. Hydrogen peroxide-inducible clone 5 (Hic-5) as a potential therapeutic target for vascular and other disorders. J Atheroscler Thromb. 2012;19(7):601-7. doi: 10.5551/jat.10736. Epub 2012 May 4. PMID: 22472216.

Adding to Further Reading:

Shibanuma M, Kim-Kaneyama JR, Ishino K, Sakamoto N, Hishiki T, Yamaguchi K, Mori K, Mashimo J, Nose K. Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal. Mol Biol Cell. 2003 Mar;14(3):1158-71. doi: 10.1091/mbc.02-06-0099. PMID: 12631731; PMCID: PMC151587.