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= Mary Jane Hogue = Mary Jane Hogue (October 12, 1883 - September 11, 1962) was an American scientist and a pioneer in human brain tissue culture. Her scientific interests encompassed multiple subfields of biological research including embryology, cancer, and neuroscience. Her work on tissue culture was heavily influenced by other female scientists at the time including Rhoda Erdmann, Margaret Reed Lewis, and Margaret R. Murray among others.

Early Life
Mary Jane Hogue was born on October 12, 1883 into a Quaker family in West Chester, Pennsylvania. She was the second of three daughters born to Thomas Clarkson Hogue (1845-1932) and Martha Jane Woolley (1851-1951). Mary Jane and her two sisters, Julia and Helena, attended the West Chester Friends School, and 1901 she graduated from the West Chester High School.

Education and Career
Hogue received her A.B. in 1905 after studying German and Biology at the Woman's College of Baltimore City, now Goucher College. She continued her education at Bryn Mawr College, where she studied planarian regeneration with Nettie Marie Stevens and starfish embryology with David H. Tennent. In 1907, Mary Jane was awarded a fellowship to study abroad at the University of Würzburg in the laboratory of Theodor Boveri and his wife Marcella. At the time, women were unable to attend the university as full students, but were allowed to audit classes. Hogue did not allow this limitation to impede her education and in 1909 she earned her PhD for her work studying centrifugal forces and blastomere potentiality in Ascaris (giant roundworm).

While an instructor at Mount Holyoke College and Wellesley College, Hogue continued her research on amoeba during the summer at the Marine Biological Laboratory (MBL) in Woods Hole, MA. During her time at the MBL she cultivated a friendship with Margaret Reed Lewis, who offered Hogue the opportunity to visit her lab in 1919 to study the response of fibroblasts of the embryonic chick heart in

In 1924 Hogue accepted a position as an instructor of anatomy at the University of Pennsylvania Medical School, where she advanced to associate professor by 1952.

Legacy
She was later recognized with Lewis and Murray by Goucher College President Kraushaar for their scientific contributions as part of the 1954 dedication of the Hoffberger Scientific Building.

Scholarships & Awards

 * Founders College Scholarship
 * Dean Van Meter Alumnae Fellowship (1907-1909)

Key Publications
Boveri, Theodor and M.J. Hogue. Über die Möglichkeit, Ascaris-Eier zur Teilung in zwei gleichwertige Blastomeren zu veranlassen. Phy-Med Gesellschaft zu Würzburg, Band 29, 1909.

Tennent, D.H. and M. J. Hogue. "Studies on the development of the starfish egg." Journal of Experimental Zoology, Vol. III, No. 4, 1906.

Hogue, M. J. "The effect of hypotonic and hypertonic solutions on fibroblasts of the embryonic chick heart in vitro." Journal of Experimental Medicine, Vol. XXX, No. 6, December 1, 1919.

Hogue, M. J. "Studies on the life history of Vahlkampfia Patuxent N, SP., parasitic in the oyster, with experiments regarding its pathogenicity." American Journal of Hygiene, Vol. I, No., 3, May, 1921.

Hogue, M. J. "The reaction of tissue-culture cells to barium (x-ray) sulfate." Anat. Rec., Vol. 54, No. 3, November, 1932.

Hogue, M. J. "A method for preventing moisture condensation during photography of tissue cultures in hanging drops." Science, Vol. 110, No. 2851, August, 1949.

Hogue, M. J. and A. Rubin. "Studies on the solid form of mouse sarcoma 37 grown in tissue culture." Cancer Research, Vol. 15, No. 7, August, 1955.

Hogue, M. J., R. McAllister, A. E. Greene, and L. L. Coriell. "The effect of poliomyelitis virus on human brain cells in tissue culture." Journal of Experimental Medicine, Vol. 102, No. 1, July 1, 1955.