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= Sulfonyl fluoride =

In organic chemistry, a sulfonyl fluoride is an organic compound with the functional group \sS(\dO)(\dO)Cl. Their formula is usually written R\sSO2F, where R is a side chain. They derivatives of sulfonic acids (R\sS(\dO)(\dO)OH).

Stuff
Also see Sulfonyl halide:

Sulfonyl fluorides
Sulfonyl fluorides have the general formula RSO2F. "Most, if not all" industrially synthesized perfluorooctanesulfonyl derivatives, such as PFOS, have the sulfonyl fluoride as their precursor.

In the laboratory, sulfonyl fluorides are used in molecular biology as reactive probes. They specifically react with residues based on serine, threonine, tyrosine, lysine, cysteine, and histidine. The fluorides are more resistant than the corresponding chlorides and are therefore better suited to this task.

Some sulfonyl fluorides can also be used as deoxyfluorinating reagents, such as 2-pyridinesulfonyl fluoride (PyFluor) and  N-tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor).

Deoxyfluorination stuff
Apart from DAST and Deoxofluor, a wide variety of similar reagents exist, including, but not limited to, 2-pyridinesulfonyl fluoride (PyFluor) and N-tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor). Many of these display improved properties such as better safety profile, higher thermodynamic stability, ease of handling, high enantioselectivity, and selectivity over elimination side-reactions.