User:Adriyan Hrycyshyn/sandbox

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Practice Editing Here (Nov 23rd in-class Wiki session work)
Heat Stroke
 * This is a place to practice clicking the "edit" button and practice adding references (via the citation button).

Assignment # 3
Proposed Changes:
 * Note: You will be emailing your assignment # 3 directly to your tutor, however, please paste a version here that excludes your personal information. This will allow us to support your efforts on Wikipedia prior to editing "live" in the article.

Along with my team member, my proposed change is an addition to a new ‘Pathophysiology’ section we are intending to add to the existing Heat Stroke article page. My addition (below) will follow my team member’s part on the heat toxicity mechanism for heat stroke:

Growing evidence also suggests the existence of a second pathway underlying heat stroke that involves heat and exercise-driven endotoxemia [1]. Although its exact mechanism is not yet fully understood, this model theorizes that extreme exercise and heat disrupt the intestinal barrier by making it more permeable and allowing lipopolysaccharides (LPS) from gram-negative bacteria within the gut to move into the circulatory system [1]. High blood LPS levels can then trigger a systemic inflammatory response and eventually lead to sepsis and related consequences like blood coagulation, multi-organ failure, necrosis, and central nervous system dysfunction [1].

[1] Lim CL. Heat Sepsis Precedes Heat Toxicity in the Pathophysiology of Heat Stroke-A New Paradigm on an Ancient Disease. Antioxidants (Basel). 2018;7(11):149. Published 2018 Oct 25. doi:10.3390/antiox7110149

Rationale for Proposed Changes:

The current article page has no reference to any pathophysiological mechanisms underlying heat stroke (unlike similar pages for ‘hyperthermia’, etc.), and adding my proposed changes helps fill that gap by providing readers with a short, broad introduction to one of the 2 main pathophysiological theories described in current literature.

Aside from offering new information to the page, my proposed addition also links a very informative and recent review article that provides an in-depth summary of primary literature related to endotoxemia-mediated heat stroke: a theory for heat stroke pathophysiology that is rarely known about compared to the conventional heat toxicity mechanism. Thus, another rationale for my addition is also to provide a bridge to further knowledge for readers exploring the topic and to introduce more readers to this novel model of heat and exercise-induced heat stroke pathophysiology. Ultimately, this could spark new Wikipedia pages surrounding this area or inspire further intrigue and research into these mechanisms.

In terms of the actual wording I chose in my proposed addition—it was challenging condensing all the relevant information in the review to a few sentences, and even more challenging phrasing the information in a way that was accessible to non-medical viewers. I decided to keep more complex words like ‘lipopolysaccharides’ and ‘endotoxemia’ since they could be linked to other Wikipedia pages for readers who wish to have more context and background information. As well, I noticed how pathophysiology sections for other diseases (‘hyperthermia’, etc.) kept scientific language to some extent, so I aimed to simplify my addition as much as possible while still maintaining scientific terminology similar to what other popular Wikipedia pages had.

Critique of Source:

Overall, the secondary source supporting my proposed addition has strong validity within the limitations of it being a critical review. This review has many strengths: it is the only review article available for this topic, it cites original references, it includes a visually-appealing diagram presenting the novel model, and the information is well-summarized in a logical order that will help readers entering the field. These strengths make me believe the article is credible and accessible, which made me comfortable citing it in my edit. However, certain weaknesses do exist:


 * Although the review itself was published in 2018, the majority of studies it cites are more than 10+ years old.  I recognize this doesn’t necessarily compromise the review’s credibility as older articles may be the originals; however, some focus on more recent research that cited those original articles could provide a more comprehensive view of the information.
 * This critical review was only written by one author.  By having only one reviewer collecting, synthesizing, and appraising information, potential for bias arises that may distort how certain studies are presented. More authors involved in the process could help reduce any possible bias arising from this issue.

What to post on the Wikipedia article talk page?

 * This will also be covered on Nov 23rd in class. Your group should use the below template to share an outline of your proposed improvements (including your new wording and citations). Article talk pages are not places to share your assignment answers. The Wikipedia community will be more interested in viewing your exact article improvement suggestions including where you plan to improve the article (which section), what wording you suggest, and the exact citation (Note: all citations must meet WP:MEDRS)
 * You will not be able to paste citations directly from your sandbox to talk pages (unless you are interested in editing/learning Wiki-code in the "source editing" mode). We suggest re-adding your citations on the talk page manually (using the cite button and populating the citation by pasting in the DOI, website, or PMID). You will have to repeat this process yet again when you edit the actual article live.
 * Talk Page Template: CARL Medical Editing Initiative/Fall 2020/Talk Page Template