User:Af2916/Ichthyotoxin

Euglonophycin
It was discovered that euglonophycin, a euglenoid ichthyotoxin derived from Euglena sanguinea, displays anticancer activity. By sharing a similar chemical structure to solenopsin, an angiogenic inhibitor and alkaloid toxin derived from fire ant venom, euglonophycin has been studied for potential application in natural products and drug development for cancer therapy. Based on experimental studies, anti-cancer activity by euglonophycin was demonstrated in leukemia, neuroblastoma, and colorectal cancer cell lines. Specifically, in colorectal cancer cells, euglenophycin exposure exhibited cytotoxic, anti-proliferative, anti-migratory, and anti-inflammatory activity. It was determined that autophagic regulation and G1 cell cycle arrest contributes to euglenophycin’s ability to inhibit colorectal cancer cell proliferation, prevent metastasis, and suppress tumor inflammation.