User:Aggiebiochemist/Centrosome Cycle

The Centrosome Cycle Centrosomes are the major microtubule organizing center (MTOC) in a mammalian cell. Centrosomes are responsible for regulation of spindle pole bipolarity and positioning. Failure of centrosome regulation can cause mistakes in chromosome segregation and is associated with aneuploidy. Centrosomes are comprised of two centrioles which are surrounded by an amorphous cloud of pericentriolar matrix. The centrosome cycle is important to ensure that daughter cells receive a centrosome after cell division. The centrosome, also, changes dynamically with cues from the cell cycle.