User:Aidan S Anderson/Evaluate an Article

Which article are you evaluating?
GalNAc-T activation pathway

Why you have chosen this article to evaluate?
Recently, post-translational modifications (PTM's) have become of interest to cell biologists studying mechanisms leading to disease states or at-large changes in cell morphology and function. O-GlcNAcylation has been shown to be clinically relevant on many fronts and as such accurate and detailed information regarding this PTM should be available to the general public.

Evaluate the article
The lead section of this article is very sparse and describes the GALA pathway in the context of one known process in cancer pathogenesis while ignoring the more broad implications of the pathways function and role in cellular homeostasis and morphology changes. The core understanding that O-GlcNAcylation is performed by GalNAc-T on substrates upon translation at the ER is suggested and loosely explained.

Content wise, again with a focus on cancer pathogenesis, a purposed mechanism is described defining a signaling cascade resulting in GalNAc-T translocation in a COPI dependent manner. This is properly executed and readers are left with a detailed understanding of this particular GalNAc-T mechanism (although alternative mechanisms exist in literature). A brief consideration for these alternative pathways is included in a summary of this pathways initial discovery by Bard & Chia.

In summation, this article exhibits sufficient explanation and detail to give readers a basic understanding of a GalNAc-T pathway in the context of cancer pathogenesis, with some relevant information provided about initial discovery. The writing could benefit from a summary diagram depicting the cellular events leading to GalNAc-T translocation and downstream O-GlcNAcylation at the ER.