User:Aishashok06/sandbox

Cytoplasmic dynein is a large protein complex that has two heavy chains along with several lighter chains. The N-terminal region (or the tail) of the heavy chain behaves as an assembly platform for the accessory chains, while the the motor domain (located at the C-Terminal) hydrolyses the ATP and is responsible for powering the movement along the microtubule. The heavy chains have a molecular weight of about 0.5-0.6 MDa each, depending on the species. The dynein heavy chain contains a ring structure having six AAA+ subunits. AAA1-AAA4 have the ability to bind ATP while AAA5 and AAA6 do not. The AAA1 has been identified as the major hydrolysis site.