User:Akennedy 4/Creatine/Anwer2007 Peer Review

Peer review
I think the subsection of Renal Function was an important addition. The part of the article that I thought could use the most improvement is the body's capacity to excrete creatine and if there is a toxic ingestion dose. Following are some suggested edits by section. Thank you for all the hard work!

History
Figure ‘The cyclic derivative creatinine exists in equilibrium with its tautomer and with creatine’ should be moved somewhere under Pharmacokinetics

Metabolic Role
Add link for amino acid Wikipedia page

Suggested structure for 1st sentence: Creatine is a naturally occurring non-protein amino acid which has a primary metabolic role of combining creatine with a phosphoryl group to generate phosphocreatine. Phosphocreatine is then used to regenerate ATP by donating its phosphoryl group to ADP.

Metabolic Role: Phosphocreatine System
Add relevant Wikipedia link for mM units

Add Wikipedia myosatellite cells page link to 'satellite cells'

Pharmacokinetics
Add Wikipedia Pharmacokinetics page link to pharmacokinetics

Add links for volume of distribution, clearance, bioavailability, mean residence time, absorption rate, and half life

Could possibly replace the term ‘pharmacokinetics of creatine’ with ‘how they body processes creatine’

Pharmacokinetics: Loading Phase
Move (total of 20g/day) to right after ‘5g creatine taken four times a day’

Change ‘equal’ to ‘equally’ in second sentence

Change ‘ergogenic benefits’ in last sentence of first paragraph to ‘ergogenic benefits (discussed in the Therapeutic Uses section)’

Change ‘mitigating diseases’ to ‘mitigate diseases that cause creatine deficiencies’.

Add a link for ‘loading dose’ Wikipedia page to 'loading phase'

Pharmacokinetics: Maintenance Phase
Add a wikipedia link for 'maintenance dose'

Pharmacokinetics: Clearance
What happens if one continues to take large doses of creatine after maximal body stores are achieved? Is there a toxic dose? Or is all the extra creatine excreted in healthy individuals?

Is creatine cleared by the kidney and/or other organs? What is it broken down to?

Perhaps add the following equation to help explain role of renal function in creatine metabolism and therefore provide a basis for concerns about renal function with creatine supplementation

Creatine -> Creatinine -> Creatinine excreted in urine

Therapeutic uses: Muscular disease
Add link for muscular dystrophies Wikipedia page

Therapeutic uses: Huntington’s Disease
Do these studies agree on effects or mostly disagree?

Add link for primary studies, systematic reviews i.e. links that explain what these terms mean

Adverse effects: Renal function
Was renal function studied with creatine supplementation at the same level as mentioned in the loading and maintenance phase sections or at any consumption rate?

Change ‘health’ to ‘healthy’ in last paragraph

Is renal disease a contraindication to creatine supplementation? Are there other common diseases which are contraindications for creatine supplementation?

Add a line saying that kidney damage can occur when creatine is taken with certain medications discussed in the Interactions section

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