User:Albuja.i/Stargardt disease

Signs and Symptoms:


 * Peripheral vision is usually less affected than fine, central (foveal) vision.... due to macular degeneration.
 * Usually a bilateral presentation (1)
 * images, requested in talk page
 * fix wording and flow

Diagnosis


 * misdiagnoses
 * As previously mentioned, genetic testing has advanced the diagnosis of Stargardt Disease beyond a phenotypic standpoint. Other diseases may have overlapping physical features with Stargardt Disease and the disease itself has multiple variants. In one study 35% of patients diagnosed with Stargardt Disease through physical ophthalmic examination were found to be misdiagnosed when subsequent genetic testing was done. (1)

Treatment


 * update: are there any current clinical trials?

Epidemiology


 * study mentioned doesn't have clear findings
 * from 2017
 * include more studies, if any

History


 * only includes original diagnosis
 * add prevalence throughout the years
 * add famous people who had it

Research


 * see if any progress has been made in any of the research mentioned especially clinical trials
 * add anything new
 * Sanofi gene therapy (SAR422459) clinical trial terminated prematurely due to halt in developing the drug product (2)
 * Alkeus Pharma (ALK-00) clinical trial enrolling by invitation, estimated completion date of December 2024 (2)
 * Kubota Vision published the results of a dose range study of emixustat with findings that will effect dose selection for their phase III trial set to complete in June 2022 (3)

Overall


 * wording and flow for everything could be better
 * images, images, images!!!

Sources


 * 1) Ibanez, MB,  de Guimarães, TAC,  Capasso, J,  Bello, N,  Levin, AV.  Stargardt misdiagnosis: How ocular genetics helps. Am J Med Genet Part A.  2021; 185A: 814– 819. https://doi-org.ezproxy.neu.edu/10.1002/ajmg.a.62045
 * 2) https://clinicaltrials.gov/ct2/home
 * 3) Kubota R, Birch DG, Gregory JK, et al Randomised study evaluating the pharmacodynamics of emixustat hydrochloride in subjects with macular atrophy secondary to Stargardt disease British Journal of Ophthalmology  Published Online First: 19 November 2020. doi: 10.1136/bjophthalmol-2020-317712