User:Alexanderwaals/Nicotinamide cofactor analogues

Got a bit confused about which order to add things, this is copy and pasted from the talk page of the article I had already written;

It may be helpful to add a note on oxidoreductases given that is enzyme group the article topic would be involved in, explaining why nicotinamide is used as a cofactor

Stating the oxidized and reduced forms,those used in anabolic vs catabolic rxns may also be useful.

A note on why analogues are needed could also be added.

Proposed Addition Notes:

Background: Oxidoreducatses are enzymes that catalyze the transfer of a hydride ion between a substrate and a cofactor, in many cases, particularly those in metabolic reactions, that cofator is a form of nicotinamide adenine dinucleotide. Nicotinamide adenine dinucleotide phosphate (NADPH) is used in anabolic reactions while nicotinamide adenine dinucleotide (NAD+) is used in catabolic reactions.

Analogues: Unlike the human body, typical chemical reactions are unable to regenerate the cofactor for further use. Synthetic cofactors have been researched to solve this problem. The analogues have been synthesized from similar compounds such as 1,4-dihydronicotinamide. These synthetic cofactors have since been used to better understand the mechanisms of reactions especially when it comes to stereospecificty, which may be enhanced by metal ions. Analogues serve as an alternative to traditional regeneration techniques.

citations

https://doi.org/10.1016/j.bbapap.2017.11.005

dx.doi.org/10.1021/cs4011056

doi.org/10.1002/anie.202017027