User:Alexniy/ELAV-like protein 1/Bibliography

Outline or changes to be made

 * Currently, there is no information on the structure of HuR, but just a very basic overview that could be expanded upon (despite its ubiquitous presence in human tissue and importance in transcriptosomal regulation compared to other proteins of the same ELAV/Hu family).
 * Expansion of description of domains and RNA binding sites.
 * Maybe: an image/visual of the various domains and their length in amino acids in the protein.
 * An addition of clinical applications or research section, such as post-translational modifications and their impact on HuR/the larger cell
 * Diseases section can include cancer, or neurodegenerative diseases whre HuR has been making notable appearances in studies.
 * Addition of PDB image of HuR 3D crystal structure.

Explanation of References
** Each scientific journal used in this article is peer-reviewed and often reference each other. This is helpful for the reputability of the article as a whole, and to avoid making misleading conclusions. I used words like, "correlated to" and "associated with," rather than "caused by" to avoid misconstruing the content of the study.
 *   Article w/ discussion of various post-translational modifications that will be discussed later. This is helpful for validating the breadth of studies on this topic/ how diverse these modifications are and their effects are.
 *   Basic info on domains of HuR and secondary/primary structure
 *   Similar to previous source
 *   A discussion of the gap sequences and linkers/secondary structure
 *   A discussion of the hinge region
 *  A greater discussion of hinge and the role of the RRM3 domain from a relatively recent time (this is scarcely discussed for other RNA binding proteins in Wikipedia due to their recency). Helpful for notability on this topic, especially for the cancer section.
 *   A consensus sequence or examination of crystal structure studies from previous years, added to following the "Structure" and "Function" conventions of many other notable proteins I have read in Wikipedia.
 *   More about mRNA binding on RRM3, not just RRM1,2 domains.
 *   Similar to previous source.
 *   The presence of HuR is significant in the human body in that it has a number of functions, but its main one is mRNA stability for cellular processes. Mentioning this is important, as HuR has been the subject of many studies related to cancers and other diseases in a diverse range of ways, noting how ubiquitous it is.
 * A reputable, peer-reviewed source to show, reliably, that HuR detaching and mRNA destabilization is linked.
 *   CDK, a well-known protein in cell cycle functions, is involved in modifying HuR on a larger scale and affecting it in the two ways mentioned previously (localization and mRNA stability).
 *   Similar to previous.
 *   Ubiquitination, two studies are mentioned, and these demonstrate two different outcomes in different cases.
 *   Similar to previous
 * A source mentioning, reliably, that this kind of methylation is common with many other mammalian proteins.
 * A short discussion of methylation and some of its impacts.
 *   Similar to previous.
 *   A broad overview of the importance of HuR in cancer which could potentially be expanded upon.

References (Bibliography)
** ''' This does not include the pre-existing citations from the ELAV-like protein 1 article.  You will be compiling your bibliography and creating an outline''' of the changes you will make in this sandbox.