User:Alexniy/Evaluate an Article

Calmodulin
Lead : as with most articles, this one has a brief snippet about the source of its name, its main targets, and its role in a popular pathway involved with the divalent cation Ca2+.

Content : As is convention, Structure contains specific information on size, number of amino acids, and interestingly, a separate sub-section on the "Importance of flexibility in calmoldulin." The features of calmoldulin are discussed. This is a relatively long article with a great deal of information on the mechanism, particularly as it pertains to cooperativity based on cation binding, affinity, and its relationship to animals/plants in different ways.

Tone and Balance: There is only neutral, and no convincing language. Most statements appear to be backed by sources.

Sources and References: Biochemistry journals that are peer-reviewed are mentioned, most of which are from the 1990s, but this was foundational information important to studies on CaM today.

Organization and Writing Quality: This is a great quality to use as a template for writing such protein-related articles in that there are headings appropriate to each section mentioned, even with extensive information about plants. However, some of this information is disproportionately more than the mammalian section. I wonder if this is due to the relevance in various studies or research today of CaM, or something that could be cut down or organized better.

Talk Page: Various discussions on ways to improve the page, especially on its relationship to Arabidopsis.

Media: Multiple representations, including the C-terminal domain, N-terminal domain, a space-filling model, and an image of Sorghum (due to CaM's role in regulation during heat stress).

Sources: Sources are reputable, peer-reviewed papers.

Overall Impression: I believe this is an excellent article that underlines the important aspects of such a ubiquitous protein in plants and mammals (i.e. all eukaryotes). Calmodulin-like (CL) proteins are not discussed in the "Calmoldulin" page despite their major role in research of the actual protein. There isn't much information on their respective pages besides that they are encoded by a "CL"-gene. There should maybe be a section about this. I posted it on the "Talk Page" as a suggestion.

My Sources:

Overview of CMLs from plants, especially their role in leguminous crops:

[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965522/#:~:text=Calmodulin%2Dlike%20proteins%20(CMLs),uncharacterized%20in%20leguminous%20crop%20plants. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965522/#:~:text=Calmodulin%2Dlike%20proteins%20(CMLs),uncharacterized%20in%20leguminous%20crop%20plants.]