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The 1920 United States Senate special election in Missouri took place on November 5, 1918 in Missouri. Democrat William J. Stone was elected to the full term in 1914, but died on April 14, 1918. Xenophon P. Wilfley was appointed to the vacant seat on April 30, 1918. He lost the Democratic primary election to Joseph W. Folk, who was defeated by Republican Selden P. Spencer in the general election.

Candidates

 * Joseph W. Folk, former governor of Missouri
 * Xenophon P. Wilfley, the incumbent Senator
 * John C. Higdon, lawyer

Candidates

 * Selden P. Spencer, former circuit court judge and former state representative for the St. Louis City-5th district
 * Jay L. Torrey, Rough Rider and former Speaker of the Wyoming House of Representatives