User:Alib2022/Glycoprotein/Lisa1235858 Peer Review

General info

 * Whose work are you reviewing?

Alib2022


 * Link to draft you're reviewing

Glycoprotein


 * Link to the current version of the article (if it exists)

Glycoprotein

Lead

 * Has the Lead been updated to reflect the new content added by your peer?
 * The critical structural element of all glycoproteins is having oligosaccharides bonded covalently to a protein. There are 10 common glycans in mammals including: glucose ... The oligosaccharide chains aid the proteins in quality control, as they identify misfolded proteins. The oligosaccharide chains also change the solubility and polarity of the proteins that they are bonded to. --These sentences reflect new information appropriate for the lead
 * There are 10 common glycans in mammals including: glucose (Glc), fucose (Fuc), xylose (Xyl), mannose (Man), galactose (Gal), N-acetylglucosamine (GlcNAc), glucuronic acid (GlcA), iduronic acid (IdoA), N-acetylgalactosamine (GalNAc), sialic acid, and 5-N-acetylneuraminic acid (Neu5Ac). --While this reflects new information, not sure if you would want to put this at the lead because it seems too specific. Maybe have it be its own subcategory?
 * Does the Lead include an introductory sentence that concisely and clearly describes the article's topic?
 * The critical structural element of all glycoproteins is having oligosaccharides bonded covalently to a protein. --Yes this concisely describes the topic
 * Does the Lead include a brief description of the article's major sections?
 * --Currently cannot determine what the major sections are going to be
 * Does the Lead include information that is not present in the article?
 * --The mammal glycan information and glycoprotein size and composition is new
 * Is the Lead concise or is it overly detailed?
 * --It's overly detailed as of right now

Content
Guiding questions:


 * Is the content added relevant to the topic?
 * --All content is relevant, just could use some rewording.
 * Is the content added up-to-date?
 * --The current content appears up-to-date
 * Is there content that is missing or content that does not belong?
 * --Currently don't see the relevance of mentioning the mammal glycans
 * Does the article deal with one of Wikipedia's equity gaps? Does it address topics related to historically underrepresented populations or topics?
 * --Doesn't apply

Tone and Balance
Guiding questions:


 * Is the content added neutral?
 * --Yes
 * Are there any claims that appear heavily biased toward a particular position?
 * --No
 * Are there viewpoints that are overrepresented, or underrepresented?
 * --No
 * Does the content added attempt to persuade the reader in favor of one position or away from another?
 * --No

Sources and References
Guiding questions:


 * Is all new content backed up by a reliable secondary source of information?
 * --Yes, they have reliable secondary sources
 * Does the content accurately reflect what the cited sources say? (You'll need to refer to the sources to check this.)
 * The content does reflect the cited sources
 * Are the sources thorough - i.e. Do they reflect the available literature on the topic?
 * --The sources are thorough
 * Are the sources current?
 * --There is a source from 2010 as of right now, but that is still considered current.
 * Are the sources written by a diverse spectrum of authors? Do they include historically marginalized individuals where possible?
 * --The ebook cited has a diverse spectrum of authors.
 * Are there better sources available, such as peer-reviewed articles in place of news coverage or random websites? (You may need to do some digging to answer this.)
 * --If you want to go into more detail about the types of glycosylation I found this article: https://www.sciencedirect.com/science/article/pii/S0167488913000669
 * Check a few links. Do they work?
 * --The links work.

Organization
Guiding questions:


 * Is the content added well-written - i.e. Is it concise, clear, and easy to read?
 * --Needs more organization because it is hard to read right now
 * Does the content added have any grammatical or spelling errors?
 * --No errors, but the sentences don't currently flow well
 * Is the content added well-organized - i.e. broken down into sections that reflect the major points of the topic?
 * --Could use more organization, but it is broken down into major points

Images and Media
Guiding questions: If your peer added images or media


 * Does the article include images that enhance understanding of the topic?
 * --It does enhance understanding of the topic
 * Are images well-captioned?
 * --The image is well captioned, maybe allude to a comparison between the two types of proteins in the caption?
 * Do all images adhere to Wikipedia's copyright regulations?
 * --Yes, it does
 * Are the images laid out in a visually appealing way?
 * --The image looks out of place as of right now

Overall impressions
Guiding questions:


 * Has the content added improved the overall quality of the article - i.e. Is the article more complete?
 * --I can see the article becoming more well-rounded this way
 * What are the strengths of the content added?
 * --They have good sources for the article
 * How can the content added be improved?
 * --Less detailed, proper citations, maybe use what the Wikipedia currently has and see how to overlap or improve information in your sandbox?
 * *to be added to another section of the article that is already written* P-glycoproteins are critical for antitumor research due to its interference in the effects of antitumor drugs. It is a type of ABC transporter, which means that it transports compounds out of cells. This includes drugs meant for cell delivery. Therefore, understanding its behavior would decrease its interference in drug delivery. ( https://www.ingentaconnect.com/content/ben/cmc/2010/00000017/00000008/art00007 ) --Do you plan on expanding on the existing explanations? If so, this is a step in the right direction
 * The formation of the link between the glycan and the protein is key element of the synthesis of glycoproteins. The most common method of glycosylation of N-linked glycoproteins is through the reaction between a protected glycan and a protected Asparagine. Similarly, an O-linked glycoprotein can be formed through the addition of a glycosyl donor with a protected Serine or Threonine. These two methods are examples of natural linkage. However, there are also methods of unnatural linkages. Some methods include ligation and a reaction between a serine-derived sulfamidate and thiohexoses in water. Once this linkage is complete, the amino acid sequence can be expanded upon using solid-phase peptide synthesis. --Do you plan to add the image here? I think it would make more sense here rather than at the lead.