User:Aliyahz/sandbox

Cornelia de Lange syndrome (CdLS) is a genetic disorder. People with this syndrome experience a range of physical, cognitive, and medical challenges ranging from mild to severe. The syndrome has a widely varied phenotype, meaning people with the syndrome have varied features and challenges. The typical features of CdLS include thick or long eyebrows, a small nose, small stature, developmental delay, long or smooth philtrum, thin upper lip and down-turned mouth.

The syndrome is named after Dutch pediatrician Cornelia Catharina de Lange, who described it in 1933.

It is often termed Brachmann de Lange syndrome or Bushy syndrome and is also known as Amsterdam dwarfism. It is a genetic disorder that in the severe form can lead to severe anomalies of physical and intellectual development. Exact incidence is unknown, but it is estimated at 1 in 10,000 to 30,000.

Diagnosis
The diagnosis of CdLS is primarily based on clinical findings by a clinical geneticist; and in some cases may be confirmed through laboratory testing.

Edits:

Diagnosis of CdLS is based on both clinical and molecular approaches. Diagnoses are primarily based on clinical findings by a clinical geneticist; and in some cases may be confirmed through laboratory test. Typical cases of CdLS are normally recognized at birth due to the classical phenotype of patients with the disorder. However, not every case is readily diagnosed, as its presentation can range from person to person and have varying effects on facial appearance and limbs.

'''Very nice start! Here is a source that might be helpful and I was curious what types of laboratory tests specifically can be used. Perhaps you might be able to add that as well to this article if you have interest (https://www.ncbi.nlm.nih.gov/books/NBK1104/). Look under Table 1 in this source for more details if you are.'''

Notes:

I would like to contribute more information and clarity to this article. SOME OF THE CITATIONS YOU HAVE BELOW ARE VERY SPECIFIC (eg, Otolaryngology). HOW ARE YOU PLANNING TO ADD TO THE ARTICLE; WILL IT COVER SUCH SPECIFIC ATTRIBUTES TO THE DISEASE? The article was rated S, so there is much to improve on in terms of the amount of information available. I would also like to really improve on the introduction. There also seem to be a few grammatical errors that can be corrected. The article is very vague and is extremely lacking in the diagnosis, treatment, and history sections. I plan on adding additional information to all of them, as I feel that none of them are well-explained or give enough information to really present coherent and reliable information to audiences (i.e. one sentence for some of the sections).