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The first two alpha chains subunits of collagen VI have a molecular weight of 140-150 KDa and the third polypeptide chain is larger with a molecular weight of 250-300kDa. Collagen VI is also found in the skin, lungs, blood vessels, cornea and intervertebral disc. It also forms part of the peripheral nerves, brain, myocardium and adipose tissue. There has been recent discoveries of Collagen VI including Col6$$\alpha$$4, Col6$$\alpha$$5 and Col6$$\alpha$$6.

Some functions of collagen VI


 * 1) It provides plants with structural support by forming a mesh of beaded microfilament.
 * 2) It plays an important role in cancer by acting as a chemotherapy resistance modulator
 * 3) They are known to anchor the basement membrane of the skin to the extracellular matrix which occurs with the help of other collagens, proteoglycans, matrilins, fibronectin and glycoprotein 1.