User:Allisonchen4/sandbox

Rough Drafts of Article Edits

Lead

Laryngeal papillomatosis, also known as recurrent respiratory papillomatosis or glottal papillomatosis, is a rare medical condition in which benign tumors (papilloma) form along the aerodigestive tract.[1][22] There are two variants based on the age of onset: juvenile and adult laryngeal papillomatosis.[21]

Causes

The risk of laryngeal papillomatosis spreading to the lungs is higher in the juvenile-onset than the adult-onset.[21]

'''The presence of HPV in the respiratory tract does not necessarily result in the development of laryngeal papillomatosis. Other factors that could be involved include immunodeficiency or other similar infections. For example, laryngeal papillomatosis may become more aggressive due to the presence of certain viruses (e.g., herpes simplex virus, Epstein-Barr virus).[22]'''

'''There are three big risk factors that contribute to the acquirement of the juvenile variant. These include:[23]'''


 * Birth history (e.g., increased time spent in vaginal delivery) and the presence of HPV in the vaginal canal. It is important to note that it is still uncertain whether caesarean delivery is a protective factor.
 * Genotype of the HPV (e.g., HPV-11)
 * Individual factors (e.g., being younger when diagnosed, which may be due to a less developed immune system).

Treatment

Typically performed using a laryngeal endoscopy, surgery can protect intact tissues and the individual’s voice, as well as ensure that the airway remains unobstructed by the disease.[22]

[21] Taliercio, S., Cespedes, M., Born, H., Ruiz, R., Roof, S., Amin, M. R., & Branski, R. C. (2015). Adult-onset recurrent respiratory papillomatosis: a review of disease pathogenesis and implications for patient counseling. JAMA Otolaryngology–Head & Neck Surgery, 141(1), 78-83.

[22] Carifi, M., Napolitano, D., Morandi, M., & Dall’Olio, D. (2015). Recurrent respiratory papillomatosis: current and future perspectives. Therapeutics and Clinical Risk Management, 11, 731.

[23] Niyibizi, J., Rodier, C., Wassef, M., & Trottier, H. (2014). Risk factors for the development and severity of juvenile-onset recurrent respiratory papillomatosis: A systematic review. International Journal of Pediatric Otorhinolaryngology, 78(2), 186-197.